Description: Member of the chrysanthemum family. Used for thousands of years and described in ancient Greek literature.
Method of Action: Parthenolid prevents migraine by interfering with aggregation of platelets in blood. Has been shown to suppress 86% to 88% of prostaglandin productions (reducing severity of inflammation that accompanies migraine) but does not inhibit cyclooxygenase.
Indications and Usage: Migraine Headache (average 24% reduction); Menstrual pain; Cold Symptoms; Depression; Arthritic Pain.
Contraindications: Do not use this product if you are pregnant or lactating without first seeking advice from your physician. Pregnant or nursing mothers; those allergic to plants of the chrysanthemum family (chamomile, ragweed, or yarrow); children under two years of age. May alter bleeding time and should not be used concomitantly with warfarin sodium or other anticoagulants. Nonsteroidal anti-inflammatory drugs (NSAILDs) may reduce effectiveness of feverfew.
Dosage and Administration: Standard dose 125 mg/day (250 mcg) of parthenolide. Used as a preventive, not an emergent treatment. Continue for two to three years.
Clinical Effect In: Four to twelve weeks.
Adverse Reactions: Allergic reactions. Liver and human peripheral blood mononuclear toxicity has been found for this product during in vitro testing. If you suspect that an herb or other supplement is making you sick, call the FDA's MedWatch hotline at 800-332-1088 or contact the agency via its website at http://www.fda.gov/medwatch.
Known Interactive Effects: Tannin complex in this product may interfere with iron absorption and should be used with caution by patients being treated for iron deficiency.
Warnings: The information above is provided for educational purposes and may not be construed as a medical prescription or as a substitute for the advice of your physician. Do not use this product without first consulting your physician especially if you are pregnant or lactating. Be advised that some herbs and dietary supplements can cause severe allergic reactions in some individuals and may also have an adverse result in conjunction with other medications, or treatments. You should regularly consult your physician in matters regarding your health and particularly in respect to symptoms and conditions which may require diagnosis or medical attention. Reevaluate use of this product after 6 months.