Description: Amino acid formed from glutamic acid by glutamate decarboxylation. The role of GABA in the biochemical psychopathology of mood disorders has been documented for over 15 years. GABA, a ligand-gated chloride channel receptor, is a neurotransmitter which is used by approximately a third of all neurons and whose interactions with the biogenic amine neurotransmitters are well characterized. Low GABA function is a consistent finding in mood disorders. Highest concentrations of GABA are found in the basal ganglia of the brain, followed by the hypothalamus, hippocampus and amygdala. It is also know to stimulate the brain to secrete increased amounts of Human Growth Hormone (hGH) to replace fat levels with lean muscle tissue.
Method of Action: Functions as the most prevalent inhibitory neurotransmitter in the central nervous system and blocks excitatory messages trying to reach the limbic system. GABA works in partnership with a derivative of Vitamin B-6, pyridoxine, to cross from the axons to the dendrites through the synaptic cleft, in response to an electrical signal in the neuron and inhibits message transmission. This helps control the nerve cells from firing too fast, which would overload the system. It also helps the pituitary gland to secrete hGH in athletes.
Indications and Usage: Anxiety Disorders including Obsessive-Compulsive Disorder, sympathetic nervous system hyperarousal , muscle spasms especially of smooth muscle (including stomach and small intestine), decreasing fat levels and increasing lean muscle tissue. Can be used to detoxify CNS from benzodiazepine antianxiety drugs. May have use in treating enlarged prostate. Use of GABA for epileptic conditions should be done under supervision of a physician. Can stimulate libido due to relaxant effect. May be useful in the treatment of attention deficit disorder. May have some benefit for individuals with high blood pressure.
Contraindications: Do not use this product if you are pregnant or lactating without first seeking advice from your physician.
Dosage and Administration: GABA should be taken 10 to 20 minutes before meals - begin with evening meal. The efficacy of GABA may be increased by the addition of : "flush-free" niacinamide (100 mg), glycine (50 mg), Vitamin B-6 (50 mg), and magnesium (40 mg) and L-tyrosine (25 (mg). Starting dosage is 200 mg once daily. Standard dose if 200 mg three times daily. Can be increased maximum of 450 mg three times daily if needed. This dosage should not be exceeded. For prostate problems 20 to 40 mg daily.
Clinical Effect In: 30 to 60 minutes. More rapid if taken sublingually.
Adverse Reactions: Excess GABA supplementation can cause increased anxiety, shortness of breath, numbness around the mouth and tingling of the extremities. Some people may experience a "flush" or tingling in the face and neck, as well as an increased heart rate immediately following administration of GABA. If you experience these symptoms reduce the amount of GABA you are taking by half for several days. If you suspect that an herb or other supplement is making you sick, call the FDA's MedWatch hotline at 800-332-1088 or contact the agency via its website at http://www.fda.gov/medwatch.
Known Interactive Effects: Can be taken with benzodiazepine drugs for short periods. No other information available.
Warnings: The information above is provided for educational purposes and may not be construed as a medical prescription or as a substitute for the advice of your physician. Do not use this product without first consulting your physician especially if you are pregnant or lactating. Be advised that some herbs and dietary supplements can cause severe allergic reactions in some individuals and may also have an adverse result in conjunction with other medications, or treatments. You should regularly consult your physician in matters regarding your health and particularly in respect to symptoms and conditions which may require diagnosis or medical attention. Reevaluate use of this product after 6 months.